High LDL and High CRP: A Deadly Combination When should you be concerned? CRP levels 3 mg/L as high risk for heart disease. To make matters worse, plaques in arteries can also release CRP into the bloodstream, perpetuating the cycle in people who already suffer from heart disease or who are at high risk. Nitric oxide is good for the cardiovascular system because it relaxes blood vessels, increases oxygen and improves blood flow throughout the body. Īdditionally, CRP reduces nitric oxide release from arteries and veins, depriving tissues of adequate blood flow. Plus, it can activate cells that line the interior of blood vessels causing them to malfunction. ĬRP increases inflammation in blood vessels and contributes to hardening of the arteries, which can eventually lead to heart disease. Researchers found that in monocyte-macrophages, CRP increases reactive oxygen species and proinflammatory cytokines, worsening oxidative stress in the body. In the lining of blood vessels, CRP lowers nitric oxide and prostacyclin release, which worsens blood flow, while increasing the inflammatory compounds (monocyte chemoattractant protein-1 ( MCP-1), interleukin-8 ( IL-8), and plasminogen activator inhibitor-1 (PAI-1)). Increases Blood Vessel DamageĬRP is not only a marker of inflammation, but it also worsens any underlying inflammation. Many chronic conditions are marked by high CRP levels, including high blood sugar, insulin resistance, high blood pressure, obesity, diabetes, gum disease, and heart disease. Its levels rise in response to chronic stress. Why is High C Reactive Protein (CRP) Bad? Signals Chronic InflammationĪpart from acute infection or injury, CRP points to chronic or systemic inflammation. Keep reading to find out about health conditions associated with high and low CRP. However, it is also a marker of low-grade inflammation and can help predict your heart disease risk. A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract.ĬRP is a protein that helps you fight infections. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at that each number in parentheses is a clickable link to peer-reviewed scientific studies. Our goal is to not have a single piece of inaccurate information on this website. ![]() They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed.
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